London Irish line up new flanker as Jamie Gibson agrees to join Leicester Tigers

London Irish have already lined up a replacement for highly rated flanker Jamie Gibson, who is set to join Leicester Tigers at the end of the season.

The club are expected to announce at least two new signings in the next couple of weeks.

And I understand advanced negotiations with a back-row forward have taken place.

Gibson is reported to be linking up with former London Irish team-mates Dan Bowden, Adam Thompstone and Richard Thorpe at Welford Road.

Leicester as a rule wait until the end of the season to announce any new signings.

But, according to the Leicester Mercury, Tigers have agreed a deal with Gibson, who played in the midweek team on England?s tour of South Africa last summer.

The 22-year-old back-row forward was initially left out of Irish?s 23-man squad for last Saturday?s Aviva Premiership match against Northampton Saints.

But he was added as a late replacement, after Sailosi Tagicakibau pulled a hamstring in the pre-match warm-up at Franklin?s Gardens, and came on 12 minutes from the end of Exiles? 40-14 defeat.

With five games of the season left, Exiles are only five points off the bottom-of-the-table relegation spot.

And director of rugby Brian Smith insisted recently that he would be basing his team selection on players' commitment, saying: ?The heart and soul of the club has to be built on strong characters and the people who want to be here.?

Bryn Evans, Tom Homer, Jebb Sinclair, Kieran Low, Guy Armitage, Pat Phibbs and Tom Smallbone have all signed new contracts this season.

But Irish face another major rebuilding exercise in the summer with the as-yet-unconfirmed departures of Matt Garvey and Jonathan Joseph to Bath and Anthony Watson to Leicester Tigers.

Exiles have already seen Alex Corbisiero snapped up by Northampton Saints, while Steve Shingler has confirmed he will be returning to Scarlets and Jack Moates will be joining London Wasps.

The futures of Max Lahiff and Alex Gray, both out of contract in the summer, remain unclear.

But Smith is confident that he can strengthen the squad significantly in the summer with the new recruits he has lined up and I understand that there are several deals that are as good as done.

Worcester Warriors' in-form?No. 8 Blair Cowan is reported to have signed for Irish.

The New Zealander's?perceived lack of bulk?is one of the reasons why he is being allowed to leave Sixways as head coach Richard Hill looks to beef up his back-row options for next season, claims the Worcester News.

There are no Premiership games for the next two weekends, while the LV= Cup is concluded, so Irish have plenty of time during the break to prepare for two crucial back-to-back home games.

Exiles continue their fight to avoid the drop when they face Worcester Warriors, in the St Patrick?s Party Day fixture on March 23, before a crunch showdown with basement club Sale Sharks on March 31.

Smith, though, insists that after last Saturday?s mauling at Northampton he and his team would prefer not to wait three weeks before being in action again.

?We want to get out there and have a go,? he said.

?We are disappointed because we rallied well late in the game.

?But we were still struggling to get the ball over the line, either because we were held up or because of a forward pass. It wasn?t our afternoon.?

He continued: ?We have to suck it up now for the next two weeks. We will give the boys a couple of days off and then we?ll be right back into it.

?You are always smarting after a defeat, and especially so after a defeat like that.?

Source: http://www.getbracknell.co.uk/sport/rugby/london_irish/s/2130284_london_irish_line_up_new_flanker_as_jamie_gibson_agrees_to_join_leicester_tigers

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Women Play Increasingly Vital Role in Peace Missions (Voice Of America)

Share With Friends: | | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/289571319?client_source=feed&format=rss

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travel & leisure: Advice That May Help You When You Are Traveling ...

By Carla Rossouw

Whether you are travelling to visit friends or for business matters such as event management, you need to have the right set of skills and knowledge to plan the trip. You need to keep in mind that planning takes in a lot of considerations. In this article, we are going to talk about the different travel tips and advices.

Create a listing for the trip! Pack your suitcase the evening before you decide to travel. Result in the necessary formulations you'll need prior to your flight. Missing a flight ticket is horrible experience that you simply never wish to experience. Don't expect an air travel could make you as comfortable as necessary on the flight. Bring your personal pillow, pillow and earphones in case your trip will probably be a lengthy one. You may even consider getting some snacks so that you can have something substantial to consume throughout your flight.

Always look at the expiration dates on your passports. Different areas of the world have different passport regulation. Some countries won't allow you to come to their country if your passport expires soon within a specific amount of time. Research your destination online to find reviews of hotels, resorts and attractions before deciding on your travel plans.

Be familiar with individuals who tell you just how they're police offers or government authorities inside a strange city. Never give someone your actual passport. Don't get in the vehicle with other people. Subscribe to online newsletters provided by most major air carriers. The savings you'll enjoy will a lot more than result in the extra email worthwhile.

If you want to bring your pet on your trip, you need to find a place that will accommodate them. Keep in mind that the places may charge you extra because of you have a unique friend who'll be with you.

Be very cautious of travel deals. You should roll your clothes when packing to make everything fit easier and prevent wrinkles. This is a lot of space in your luggage. This should help bring down the needed baggage necessary for your trip.

If you are planning to travel with your dog, you need to make sure that you give your dog a good bath before travelling. You should also brush its fur thoroughly to make sure nothing will stick into your car once your dog sits there. Pets need to be taken care of carefully and you need to make sure they have all the things they need.

The preceding article showed you that there are many different ways to reduce the amount of hassle involved in traveling and event companies. Can you start making a list and preparing for your upcoming trip now?

About the Author:

Learn more about travel guiding, stop by Carla's site where you can find everything about Travel blog and Hotel Reviews to help you choose the best place to stay in during your vacation.

Source: http://bidding-travel.blogspot.com/2013/03/advice-that-may-help-you-when-you-are.html

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Samsung Galaxy S3 Among 20 Phones To Receive CyanogenMod 10.1 Android 4.2.2 Update

CyanogenMod, a free, community built, aftermarket firmware distribution for Android operating systems offers customized versions of the latest OS that can be installed on devices independent of its original firmware. Such ROMs are often used in order to attain specs and features not available on official firmware distributed by vendors of the supported devices, or in order to get OS updates much quicker that they are released by vendors.

The latest version of its more stable ?Monthly? release for Jelly Bean has been pushed out fairly quickly since its initial CM10.1-M1 release in mid-January. Then seen on only a handful of phones, M2 is now available for the following 20 devices:

Acer Iconia a700

Google Nexus S (crespo, crespo4g)

Google Nexus 7 (grouper, tilapia)

Google Galaxy Nexus (toro, toroplus, maguro)

Google Nexus 4 (mako)

Google Nexus 10 (manta)

Google Nexus Q (steelhead)

Hardkernel Odroid-U2

HTC One X (evita)

HTC Incredible 4G LTE (fireball)

HTC Evo 4G LTE (jewel)

HTC One S (ville)

LG Nitro HD (p930)

LG Optimus LTE (su640)

LG Spectrum (vs920)

Samsung Galaxy S (captivatemtd, galaxysbmtd, galaxysmtd, epicmtd)

Samsung Galaxy SII (i9100g, hercules, skyrocket)

Samsung Galaxy SIII (US variants d2att, d2cri, d2mtr, d2spr, d2tmo, d2vzw)

Samsung Note (quincytmo, quincyatt)

Samsung Galaxy Tab 2 7.0 (p3100, p3110)

Samsung Galaxy Tab 2 10.1 (p5100, p5110)

While some mobile carries have begun pushing out the Android 4.2.2 update, some others see their most popular phones still suck on even Android 4.1.1. For example, Sprint has rolled out its Android 4.1.2 update for the Galaxy S3, and Verizon recently announced that it will soon roll out 4.1.2, while AT&T, U.S. Cellular and T-Mobile have yet to do so, according to Gotta Be Mobile.

Samsung Galaxy S4: What are they waiting for?

Since the release of Android 4.2 in November 2012, such phones as the LG Nexus 4 and Samsung's Nexus 10 have tasted ?A new flavor of Jelly Bean,? as the OS?s slogan from Google suggests.

Meanwhile the progression of the highly anticipated release of the Samsung Galaxy S4 has many predicting that the Korean-based Company and mobile carriers alike may be holding out on updating a number of their more popular devices until the S4 is on the market or much closer to being released.

A rumored April or May release for the smartphone may see consumers waiting for the phone?s debut ? as it is expected to run Android 4.2.2 Jelly Bean natively ? as opposed to waiting for an update for an older OS on an older device.

With Samsung reportedly working toward a lofty sales goal of 100 million handsets in 2013, the company may be attempting to shift focus from its old phones to its new device that is already projected as its bestselling for the year.?

Source: http://www.ibtimes.com/samsung-galaxy-s3-among-20-phones-receive-cyanogenmod-101-android-422-update-1112455

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Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury

Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury

Tuesday, March 5, 2013

Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.

Alvaro Estevez, an associate professor at the University of Central Florida's College of Medicine, led the multi-university team that made the discovery, which could eventually help scientists develop new therapies to combat a host of conditions from stroke to Lou Gehrig's disease

Researchers have long known that oxidative stress damages cells and results in neurodegeneration, inflammation and aging. It was commonly believed that oxidation made a "crude," demolition-like attack on cells, causing them to crumble like a building in an earthquake, Estevez said. However, the latest findings show that oxidation results in a much more targeted attack to specific parts of the cell. Oxidative stress damages a specific "chaperone" cell protein called Hsp90. It plays a role in up to 200 different cell functions. But when a form of oxidative stress called tyrosine nitration modifies that protein, it turns into the cell "executioner" shutting it down.

"The concept that a protein that is normally protective and indispensable for cell survival and growth can turn into a killing machine, and just because of one specific oxidative modification, is amazing," said Maria C. Franco, a postdoctoral associate at UCF's Burnett School of Biomedical Sciences. She co-wrote the study. "Considering that this modified protein is present in a vast number of pathologies, it gives us hopes on finding new therapeutics approaches for several different diseases."

For example, researchers could devise a drug that stroke patients could take at the onset of their symptoms to prevent more healthy cells from dying, thus limiting the damage of the stroke. Because oxidation is linked to inflammation, researchers believe tyrosine nitration could also be related to other health problems including heart disease, cancer, aging and chronic pain.

"These are very exciting results and could begin a major shift in medicine," said Joseph Beckman, from Oregon State University Environmental Health Sciences Center, a collaborator on the study. "Preventing this process of tyrosine nitration may protect against a wide range of degenerative diseases."

"Most people think of things like heart disease, cancer, aging, liver disease, even the damage from spinal injury as completely different medical issues," Beckman said. "To the extent they can often be traced back to inflammatory processes that are caused by oxidative attack and cellular damage, they can be more similar than different. It could be possible to develop therapies with value against many seemingly different health problems."

###

University of Central Florida: http://www.ucf.edu

Thanks to University of Central Florida for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127130/Discovery_of__executioner__protein_opens_door_to_new_options_for_stroke_ALS__spinal_cord_injury

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New Galaxy Style Crystal Chandelier Pieces Now on Sale at KingdomLightingUSA.com

Online lighting retailer Kingdom Lighting has just introduced new discounts on its Galaxy collection of crystal chandeliers.

FOR IMMEDIATE RELEASE / PRURGENT

Kingdom Lighting, a retailer specializing in luxury light fixtures, is now offering customers new, limited-time deals on crystal chandeliers from its Galaxy collection. Available online at http://www.KingdomLightingUSA.com, these chandeliers feature attractive, avant-garde designs perfect for homes with modern decorative schemes.

?Kingdom Lighting?s Galaxy collection includes pendant and planet chandeliers with compellingly modern designs. Built from the finest materials and perfected by our rigorous quality standards, these fixtures are built to transform and inspire. From larger rooms to entrances and hallways, the light fixtures in the collection can brighten up any space in the home,? said Eliezer Mihaly, CEO of the Maria Theresa chandelier retailer.

One of the collection?s featured chandeliers that?s appropriate for any moderately sized space is the 5 Light Planet Modern Pendant Crystal Chandelier. Measuring 26? high, this fixture is designed to add sparkle to entryways or rooms with lower ceilings. The chandelier?s pendant crystals hang in the shape of a planet with a dazzling ring. A chrome and crystal finish gives the fixture a reflective sheen, while solid steel construction adds durability for long-lasting illumination. Kingdom Lighting carries this Galaxy collection chandelier for just $399.99, a savings of $300 off the item?s original price of $699.99.

For slightly bigger spaces, the 7 Light Pendant Crystal Chandelier is a fitting choice. This chandelier sports an intricate display of full-lead crystals and polished chrome, and includes seven GU10 lights. The fixture has dimensions of 20? x 36?, a moderate size that enables the piece to function well within almost any room, and its crystals are all hand-cut and -polished to ensure that they are of the highest quality. Kingdom Lighting is now retailing this crystal Galaxy collection chandelier at just $850, a 54% discount from its list price.

Customers decorating larger spaces, like ballrooms and dining rooms, may be interested in the 14 Light Crystal Chandelier. This piece has a tiered construction designed to create dynamic lighting in even the most spacious rooms. At 60? in height, the standout item from the Galaxy collection will make a dramatic statement and become a brilliant centerpiece wherever it is suspended. This solid steel chandelier boasts 14 lights and a multitude of shimmering, hand-cut crystal drops. Kingdom Lighting sells this chandelier for $1,799.99, a savings of $600 off its original price.

To complement these discounts, Kingdom Lighting also offers its customers a number of shopping incentives, from free shipping on orders totaling over $250 to weekly coupons allowing shoppers to claim additional savings. The company?s site also features lighting tips and guides to help owners get the most out of their crystal chandeliers.

For more information about the Galaxy collection, or to browse the rest of Kingdom Lighting?s selection, visit the retailer online at http://www.KingdomLightingUSA.com or call 1-877-6-KINGDOM. Kingdom Lighting is also available on Facebook at http://www.facebook.com/KingdomLightingUSA and Twitter at http://twitter.com/KingdomLighting, and it blogs about decorative lighting fixtures at http://www.KingdomLightingUSABlog.com.

Source: http://www.prurgent.com/2013-03-05/pressrelease288293.htm

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Exxon Mobil begins defense in gas additive case

CONCORD, N.H. (AP) -- A former Exxon Mobil engineer testified Monday that environmental hazards surrounding the gasoline additive MTBE were widely discussed in water quality and oil industry circles in the mid-1980s, contradicting the state of New Hampshire's allegations that the oil giant hid its concerns about the product.

Barbara Mickelson was the first witness as lawyers for Exxon Mobil Corp. began presenting their defense against the state's claim that it is owed hundreds of millions of dollars to clean up groundwater contamination caused by MTBE. Jurors had last week off after spending six weeks hearing the state's case, and the defense is expected to take just as long presenting its side.

New Hampshire filed its product liability lawsuit a decade ago against 26 oil companies and distributers, claiming that MTBE ? methyl tertiary butyl ether ? is a defective product because of its propensity to travel farther and faster and contaminate larger quantities of water than gasoline without additives. The state is seeking more than $700 million to test and monitor 250,000 private wells and clean up an estimated 5,600 contaminated sites, and so far has collected more than $120 million in settlement money.

Lawyers for Exxon Mobil, the only defendant that has not settled with the state, argue that MTBE did exactly what it was supposed to do ? replace lead in gasoline and cut smog in compliance with the 1990 Clean Air Act. They opened their case by attempting to cast doubt on state witnesses who claimed to be surprised by memos Mickelson wrote describing environmental concerns about MTBE. Former Department of Environmental Services Commissioner Robert Varney testified earlier that he was shocked Exxon Mobil did not share Mickelson's findings with the state, but Mickelson said the information was widely available at the time.

Mickelson, who worked for Exxon from 1984 to 1987, described national conferences she attended along with other oil industry representatives, academic researchers, and state and federal regulators at which papers were presented about the environmental risks posed by MTBE. Though Exxon wasn't using MTBE at the time, other oil companies were, and they gave presentations about problems they had with gasoline leaks, she said. She also testified that she had discussed MTBE with Maryland officials and the federal Environmental Protection Agency. That was part of a joint investigation with Gulf Oil after gasoline containing MTBE leaked from a Gulf tank and mingled with non-MTBE gasoline from an Exxon tank at gas stations located next to each other.

Before the jury returned Monday, Exxon Mobil lawyers tried to win permission to expand Mickelson's testimony, but the state's lawyers objected, saying her testimony shouldn't be used to prove what the state knew or didn't know about MTBE at the time. Noting that the judge already had ruled that Mickelson's testimony should be limited, attorney Jessica Grant said it was "grossly inappropriate" to continue arguing about it.

"At some point, they just have to live with it," she said.

But Exxon Mobil lawyer James Quinn countered that Mickelson should be allowed to explain that MTBE concerns were publicly discussed, given that the state has "made this whole case about us hiding things from people," and has maintained that state officials were shocked at Mickelson's memos.

"We need to respond to it. Fair is fair," he said.

While other lawsuits have been brought by municipalities, water districts or individual well owners, New Hampshire is the only state to have reached the trial stage in a lawsuit over MTBE. Most cases filed in the past decade have ended in settlements. New York City in 2009 won a $106 million federal jury verdict against Exxon Mobil for MTBE contamination of city wells; that verdict has been appealed.

Source: http://news.yahoo.com/exxon-mobil-begins-defense-gas-201928534.html

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